In a remarkable development detailed in the article, “A Versatile Hermetically Sealed Microelectronic Implant for Peripheral Nerve Stimulation Applications,” published on the National Center for Biotechnology Information, unveils a groundbreaking neurostimulation platform. This platform introduces a fully implantable multi-channel neural stimulator designed for chronic experimental studies involving peripheral nerves in large animal models. Notably, the implant is hermetically sealed within a ceramic enclosure and encapsulated in medical-grade silicone rubber, ensuring both longevity and safety.

The stimulator’s microelectronics are implemented using advanced 0.6-μm CMOS technology. They incorporate a crosstalk reduction scheme to minimize cross-channel interference, ensuring precision in stimulation. Additionally, high-speed power and data telemetry enable battery-less operation, a significant advancement in the field. A wearable transmitter, equipped with a Bluetooth Low Energy radio link, and a customized graphical user interface, offer real-time and remotely controlled stimulation, adding to the device’s versatility.

This versatile implant comprises three parallel stimulators, each supporting independent stimulation on three channels. Each stimulator further facilitates six stimulating sites and two return sites through multiplexing. As a result, the implant can support stimulation at up to an impressive 36 different electrode pairs, enabling highly programmable and selective neural stimulation.

The article delves into the intricate details of the implant’s design, the method of hermetic packaging, and its exceptional electrical performance. Furthermore, in vitro testing with electrodes in saline solution underscores the device’s efficacy and safety.

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